Liberal transfusion strategy to prevent mortality and anaemia-associated,...
AbstractBackgroundPerioperative anaemia leads to impaired oxygen supply with a risk of vital organ ischaemia. In healthy and fit individuals, anaemia can be compensated by several mechanisms. Elderly...
View ArticleGastrointestinal dysfunction in the critically ill: a systematic scoping...
AbstractBackgroundGastrointestinal (GI) dysfunction is frequent in the critically ill but can be overlooked as a result of the lack of standardization of the diagnostic and therapeutic approaches. We...
View ArticleBiomarkers in critical care nutrition
AbstractThe goal of nutrition support is to provide the substrates required to match the bioenergetic needs of the patient and promote the net synthesis of macromolecules required for the preservation...
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Omega-6 sparing effects of parenteral lipid emulsions—an updated systematic...
AbstractBackgroundParenteral lipid emulsions in critical care are traditionally based on soybean oil (SO) and rich in pro-inflammatory omega-6 fatty acids (FAs). Parenteral nutrition (PN) strategies...
View ArticleBaseline characteristics and outcome for aneurysmal versus non-aneurysmal...
AbstractThis study aims to investigate the characteristics of patients with mild aneurysmal and non-aneurysmal perimesencephalic and non-perimesencephalic subarachnoid hemorrhage (aSAH, pmSAH, npmSAH)...
View ArticleErfassung und apparatives Monitoring des Ernährungsstatus von Patient*innen...
ZusammenfassungDie Erhebung des Ernährungsstatus zum Zeitpunkt der Aufnahme im Intensiv- oder Intermediate Care Bereich hat sowohl prognostische als auch therapeutische Relevanz im Hinblick auf die...
View ArticleEvaluation of the cardioprotective potential of extracellular vesicles – a...
AbstractCardiovascular diseases are the main cause of death worldwide, demanding new treatments and interventions. Recently, extracellular vesicles (EVs) came in focus as important carriers of...
View ArticleElevated circulating CD14++CD16+ intermediate monocytes are independently...
AbstractElective cardiac surgery has low procedural complications. However, about 40% of patients develop extracardiac complications including delirium and acute kidney injury. We hypothesized that...
View ArticleSLPI - a Biomarker of Acute Kidney Injury after Open and Endovascular...
AbstractAcute kidney injury (AKI) is a relevant complication following thoracoabdominal aortic aneurysm repair (TAAA). Biomarkers, such as secretory leucocyte peptidase inhibitor (SLPI), may enable a...
View ArticleAdministration of vitamin D and its metabolites in critically ill adult...
AbstractBackgroundThe clinical significance of vitamin D administration in critically ill patients remains inconclusive. The purpose of this systematic review with meta-analysis was to investigate the...
View ArticleClinical nutrition issues in 2022: What is missing to trust supplemental...
AbstractA multidisciplinary group of international physicians involved in the medical nutrition therapy (MNT) of adult critically ill patients met to discuss the value, role, and open questions...
View ArticleSupplementierung von Vitamin C und D bei kritisch Kranken
ZusammenfassungDer Supplementierung von Mikronährstoffen als Bestandteil der medizinischen Ernährungstherapie kritisch kranker PatientInnen auf der Intensivstation fand in den letzten Jahren zunehmend...
View ArticleIntravenous vitamin C monotherapy in critically ill patients: a systematic...
AbstractBackgroundA recent landmark randomized controlled trial (RCT) in septic patients demonstrated an increased risk of death and persistent organ dysfunction with intravenous Vitamin C (IVVC)...
View ArticleLaborchemisches und kalorimetrisches Monitoring der medizinischen...
ZusammenfassungDieses zweite Positionspapier der Sektion Metabolismus und Ernährung der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin (DIVI) gibt Empfehlungen zum...
View ArticleBiomechanical assessment of remote and postinfarction scar remodeling...
AbstractThe importance of collagen remodeling following myocardial infarction (MI) is extensively investigated, but little is known on the biomechanical impact of fibrillar collagen on left ventricle...
View ArticleDecrease of renal resistance during hypothermic oxygenated machine perfusion...
AbstractHypothermic oxygenated machine perfusion (HOPE) was recently tested in preclinical trials in kidney transplantation (KT). Here we investigate the effects of HOPE on extended-criteria-donation...
View ArticleEndoplasmic reticulum stress and the unfolded protein response in skeletal...
AbstractWe provide a descriptive characterization of the unfolded protein response (UPR) in skeletal muscle of human patients with peritoneal sepsis and a sepsis model of C57BL/6J mice. Patients...
View ArticleMapping the cardiac vascular niche in heart failure
AbstractThe cardiac vascular and perivascular niche are of major importance in homeostasis and during disease, but we lack a complete understanding of its cellular heterogeneity and alteration in...
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